Glioblastoma Spheroid Invasion through Soft, Brain‐Like Matrices Depends on Hyaluronic Acid–CD44 Interactions (Adv. Healthcare Mater. 14/2023)
نویسندگان
چکیده
Glioblastoma Tumors (GBM) tumors aggressively invade the brain and are highly lethal. Hyaluronic acid (HA), a polysaccharide ubiquitous in extracellular matrix, is overexpressed GBM tumors. Using patient-derived cells engineered, 3D culture microenvironments, article 2203143 by Stephanie K. Seidlits co-workers demonstrates biphasic relationship between invasive activity HA concentration that depends on phosphorylation of ezrin downstream CD44 receptor.
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ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2023
ISSN: ['2192-2640', '2192-2659']
DOI: https://doi.org/10.1002/adhm.202370071